Should one  follow signs?  I generally do. This was mentioned by Reb Nachman as being a lower level of awareness, but even so it has validity. But one can get too involved in it. When the Dark Side notices one is following signs, then it begins to send signs of its own.
It works better when it is spontaneous--that is when one is not looking, and then out of the blue comes some sign. A friend of mine Moshe, suggested that signs are the result of the higher realms of reality sending messages into this realm.  A lot depend on what god one is following.