For example the challenge of Berkley where he shows that there is something incongruous about the Aristotle idea of knowledge. For Aristotle we know the fire is hot because the form of the fire comes into the head. Berkley shows that there is nothing of the hotness of the fire that comes into the head to make me understand that fire is hot. (See Thomas Reid) There are also problems with combining any sort of Platonic system with Monotheism. [i.e, in Torah you must preserve Divine Simplicity. God is not a composite..
And I do not think these issues can be ignored. So you have to deal with these issues somehow or other.
Kant and Hegel are I think the only two still standing after 200 years of Philosophy. I mean to say like Robert Hanna "forward to Kant". --that almost everything that came after these two had some good points here and there, but that is like looking for needles in a haystack. E.g. Wittgenstein had a great point to show how Husserl was wasting his time. But not much in any other way. That seems to be the main thing about everyone after Kant of Hegel-- they get one point very well and everything else wrong. [However I think the Kant Friesian School does make progress.]