חכם עדיף מנביא a wise man is better than a prophet. And Rav Nahman brings in the Sefer HaMidot that a prophet only knows what is revealed to him. So there is no question why certain people with great spiritual insight might have been completely  unaware of what should have been obvious.
There is no reason to think that Isaiah the prophet would have known Quantum Physics. The reason is spiritual values are not the same as universals which are recognizable by reason. And if he would have known QM it would only have been through reason, not prophecy--for prophecy deals with a different area of value